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- Warren Oates
- Merle Oberon
- Edmond O’Brien
- Margaret O’Brien
- Pat O’Brien
- Carroll O’Connor
- Donald O’Connor
- Nick Offerman
- Catherine O’Hara
- Maureen O’Hara
- Gary Oldman
- Laurence Olivier
- Edward James Olmos
- Elizabeth Olsen
- Nancy Olson
- Timothy Olyphant
- Ryan O’Neal
- Tatum O’Neal
- Ed O’Neill
- Peter O’Toole
- Maureen O’Sullivan
- Clive Owen
- David Oyelowo
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